Yu Meng

Yu Meng

OFFICE: GEH B421

EMAIL: ymeng@kean.edu

COURSE TAUGHT:General Biology I and II, Principles of Biology, Genetics

EDUCATION BACKGROUND:

Ph.D. Biochemistry and Molecular Biology, Clemson University, SC, USA

B.S. Biotechnology, Wuhan University, China

RESEARCH INTERESTS:

  • Drug delivery system; Protein engineering; Neurodegenerative disease
  • Efficacy and mechanism study of the effective drug carrier targeting at the blood-brain barrier for the treatment of a series of neurodegenerative disorders.

RESEARCH PUBLICATIONS:

  • Michelena, X. Tian, X. Zhou, Y. Meng. “The Impact on the Activity of Acetylcholinesterase of a Polylysine-ApoE Peptide Carrier Targeting the Blood Brain Barrier”, Fundam. Toxicol. Sci., 2018, 5(3): 123-126.
  • Meng, J. Wiseman, Y. Nemtsova, D. Moore, J. Guevarra, K. Reuhl, W. Banks, R. Daneman, D. Sleat, P. Lobel. “A Basic ApoE-Based Peptide Mediator to Deliver Proteins across the Blood-Brain Barrier: Long-Term Efficacy, Toxicity, and Mechanism”, Molecular Therapy, 2017, pii: S1525-0016(17)30158-2.
  • Wiseman, Y. Meng, Y. Nemtsova, P. Matteson, J. Millonig, D. Moore, D. Sleat, P. Lobel. “Chronic Enzyme Replacement to the Brain of a Late Infantile Neuronal Ceroid Lipofuscinosis Mouse Has Differential Effects on Phenotypes of Disease”, Mol Ther Methods Clin Dev, 2017, 4:204-212.
  • Meng. “The Role of a Conserved Tryptophan Residue in Acetyl-Coenzyme A Synthetase”, Chinese Journal of Biochemistry and Molecular Biology, 2016, 32:1219-1226.
  • Meng, I. Sohar, D. Sleat, R. Jenkins, G. Sarkar, J. Richardson, P. Lobel. “Effective treatment of late-infantile neuronal ceroid lipofuscinosis by peptide-mediated delivery of tripeptidyl peptidase I across the blood-brain barrier in a mouse model”, Molecular Therapy, 2014, 22: 547-53.

ACHIEVEMENT:

Grants as PI:

  • National Natural Science Foundation of China (NSFC), Youth Research Award 01/2018-12/2020
  • Zhe Jiang Province Natural Science Foundation (ZJNSF) Research Award 01/2016-12/2018
  • Wenzhou Science and Technology Bureau Research Award       01/2018-12/2019
  • Wenzhou-Kean University Student Partnering Faculty (SpF) Research Award 11/2015-06/2016

RESEARCH PROJECT:

National Natural Science Foundation of China Program

Mechanism of a novel and efficient in-trans drug carrier K16ApoE across the blood-brain barrier

Zhejiang Provincial Natural Science Foundation of China

Study on the mechanism of new peptide carriers mediating drug crossing the blood-brain barrier

Wenzhou Municipal Science and Technology Bureau

Construction of the Chimera by Polypeptide K16ApoE and Lysosomal Enzyme TPP1 and Its Effect on Conquering Blood Brain Barrier

RESEARCH NEWS:

Two major R&D projects of WKU regained Sci-Tech funds of Wenzhou

National Natural Science Foundation of China – Youth Science Fund