Lixiong Dai, Ph.D.


Lixiong Dai, joined the Wenzhou Institute of the University of Chinese Academy of Sciences in April 2020 as a post researcher, and a member of the Rare Earth Molecular Materials and Supramolecular Devices Professional Committee of the Chinese Rare Earth Society. He graduated from Hunan University of Science and Technology in 2007 with a bachelor’s degree, and then worked in a listed pharmaceutical company for 5 years in drug small molecule research and development. From 2012 to 2020, he studied and worked at Hong Kong Baptist University and The Hong Kong Polytechnic University. Mainly engaged in the research of lanthanide metal complexes. He developed a series of chiral macrocyclic chelators and complexes which have broad applications in magnetic resonance imaging (MRI), optical molecular imaging and radiological diagnosis and treatment. In the past five years, he has published academic papers and applied for PCT patents in academic journals such as Nat. Commun., Angew. Chem., Int. Ed., Chem. Sci., Inorg. Chem. He is presiding over a number of scientific research projects, including the Key Program of Natural Science Foundation of Zhejiang Province of China, the General Program of National Natural Science Foundation of China, and the Major Program of Wenzhou Institute of University of Chinese Academy of Sciences.


  1. 05/2014-04/2017: PhD (Inorganic Biochemistry), Department of Chemistry, Hong Kong Baptist University, Hong Kong, China
  2. 09/2003-06/2007: BSc (Applied Chemistry), Department of Chemistry and Chemical Engineering, Hunan University of Science and Technology, China

Academic Experience

  1. 04/2020-present: Associate Professor, Wenzhou institute, University of Chinese Academy of Sciences, Wenzhou, China
  2. 05/2017-04/2020: Postdoctoral Fellow, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, China
  3. 09/2007-10/2012: Organic / Pharmaceutical Synthesis, Pharmaron, Beijing, China

Research Interests

  1. Developmentofmore efficient and safer MRI contrast agents
  2. Development of more efficient radiometal chelators for radioimmunotherapy
  3. Synthesis of luminescent lanthanide materials for bio-imaging
  4. Synthesis of chiral lanthanide complexes for circularly polarized luminescence (CPL) applications

Selected Research Publications

  1. Dai, L.; Jones, C.M.; Chan, T-K.; Pham, T.A.; Ling, X.; Gale, E.M.; Rotile, N.J.; Tai, C.-S.; Anderson, C.J.; Caravan, P.; Law, G.-L.,Chiral DOTA chelators as an improved platform for biomedical imaging and therapy applications. Nature Communications 2018, 9 (1), 857.
  2. Dai, L.; Lo, W.-S.; Gu, Y.; Xiong, Q.; Wong, K.-L.; Kwok, W.-M.; Wong, W.-T.; Law, G.-L. Breaking the 1,2-HOPO barrier with a cyclen backbone for more efficient sensitization of Eu(III) luminescence and unprecedented two-photon excitation properties. Chemical Science 2019,10 (17), 4550. (inside cover,hot article)
  3. Dai, L.; Zhang, J.; Chen, Y.; Lewis, M.; Pal, R.; Law, G.-L. Synthesis of Water-soluble Chiral DOTA Lanthanide Complexes with Predominantly Twisted Square Antiprism Isomers& CPL Emission.Inorganic Chemistry 2019, 58, 12506-12510
  4. Dai, L.; Lo, W.-S.; Zhang, J.; Law, G.-L., One-Step Reaction for Screening of Chromophores to Improve the Luminescence of Lanthanide Complexes. Asian Journal of Organic Chemistry 2017,6 (12), 1845-1850.
  5. Dai, L.; Lo, W.-S.; Coates, I. D.; Pal, R.; Law, G.-L., New Class of Bright and Highly Stable Chiral Cyclen Europium Complexes for Circularly Polarized Luminescence Applications. Inorganic Chemistry 2016, 55 (17), 9065-9070.
  6. Zhang, J.; Dai, L.; Webster, A.M.; Chan, W.T.K.; Mackenzie, L.; Pal, R.; Cobb, S.L.; and Law, G.-L., Unusual Magnetic Field Responsive Circularly Polarized Luminescence Probes with Highly Emissive Chiral Eu(III) Complexes. Angewandte Chemie-International Edition2020, ASAP. doi:10.1002/anie.202012133.