Yu Meng, Ph.D.

Ph.D. Biochemistry and Molecular Biology, Clemson University, SC, USA

B.S. Biotechnology, Wuhan University, China

RUTGERS UNIVERSITY – PISCATAWAY, NJ                                             01/2010-2015

Research Associate in Center for Advanced Biotechnology and Medicine Principal Investigator: Peter Lobel

• Pharmacokinetics and pharmacodynamics study of a novel peptide mediated intravenous delivery system in preclinical mouse model of a neurodegenerative lysosomal storage disease (Late infantile neuronal ceroid lipofuscinosis-LINCL).
• Investigation of the molecular mechanism of the novel peptide in mediating delivery of large molecule therapeutics across blood brain barrier into the brain.
• Characterization of intrathecal enzyme replacement therapy for LINCL.  Identification of biomarkers in LINCL mouse model.

CLEMSON UNIVERSITY – CLEMSON, SC                                               08/2005-12/2009

Graduate Research Assistant in Department of Genetics and Biochemistry

• Expression and purification of an archaeal medium-chain acyl-CoA synthetase (ACS).  Characterization of the enzymatic mechanism of ACS.
• Construction, production and structure modeling of ACS variants.

CHINESE ACADEMY OF SCIENCE – BEIJING, CHINA                           01/2004-06/2004

Research Assistant in Molecular Microbiology Research Center

• Molecular cloning of system specific promoter and construct expression vectors for C4 plant

• Drug delivery system; Protein engineering; Neurodegenerative disease
• Efficacy and mechanism study of the effective drug carrier targeting at the blood-brain barrier for the treatment of a series of neurodegenerative disorders.

National Natural Science Foundation of China Program

Mechanism of a novel and efficient in-trans drug carrier K16ApoE across the blood-brain barrier

Zhejiang Provincial Natural Science Foundation of China

Study on the mechanism of new peptide carriers mediating drug crossing the blood-brain barrier

Wenzhou Municipal Science and Technology Bureau

Construction of the Chimera by Polypeptide K16ApoE and Lysosomal Enzyme TPP1 and Its Effect on Conquering Blood Brain Barrier

Grants as PI:

• National Natural Science Foundation of China (NSFC), Youth Research Award 01/2018-12/2020
• Zhe Jiang Province Natural Science Foundation (ZJNSF) Research Award 01/2016-12/2018
• Wenzhou Science and Technology Bureau Research Award       01/2018-12/2019
• Wenzhou-Kean University Student Partnering Faculty (SpF) Research Award 11/2015-06/2016

• Michelena, X. Tian, X. Zhou, Y. Meng. “The Impact on the Activity of Acetylcholinesterase of a Polylysine-ApoE Peptide Carrier Targeting the Blood Brain Barrier”, Fundam. Toxicol. Sci., 2018, 5(3): 123-126.

• Meng, J. Wiseman, Y. Nemtsova, D. Moore, J. Guevarra, K. Reuhl, W. Banks, R. Daneman, D. Sleat, P. Lobel. “A Basic ApoE-Based Peptide Mediator to Deliver Proteins across the Blood-Brain Barrier: Long-Term Efficacy, Toxicity, and Mechanism”, Molecular Therapy, 2017, pii: S1525-0016(17)30158-2.

• Wiseman, Y. Meng, Y. Nemtsova, P. Matteson, J. Millonig, D. Moore, D. Sleat, P. Lobel. “Chronic Enzyme Replacement to the Brain of a Late Infantile Neuronal Ceroid Lipofuscinosis Mouse Has Differential Effects on Phenotypes of Disease”, Mol Ther Methods Clin Dev, 2017, 4:204-212.

• Meng. “The Role of a Conserved Tryptophan Residue in Acetyl-Coenzyme A Synthetase”, Chinese Journal of Biochemistry and Molecular Biology, 2016, 32:1219-1226.

• Meng, I. Sohar, D. Sleat, R. Jenkins, G. Sarkar, J. Richardson, P. Lobel. “Effective treatment of late-infantile neuronal ceroid lipofuscinosis by peptide-mediated delivery of tripeptidyl peptidase I across the blood-brain barrier in a mouse model”, Molecular Therapy, 2014, 22: 547-53.