Xingjie Zan, Ph.D.


Zan graduated from Changchun Institute of Applied Chemistry Chinese Academy of Science with PhD in Polymer chemistry and Physics. Since then, he was trained in the University of South Carolina and Institute of Georgia Technology, aiming to modulation the differentiation and orientation of cells in tissue engineering and the design of novel drug delivery system. In 2014, he was awarded the “Advanced Researcher of Alexander von Humboldt Scholarship” funded by the Humboldt Foundation of Germany. In 2015, he won the “Abroad Talents Programs of Wenzhou”. Zan is currently a full research professor at Wenzhou Institute, University of Chinese Academy of Science. He is committed to the development of medical functional materials with disease treatment and tissue regeneration or repair functions. He has received grants nearly RMB 7 million and published more than 40 peer-reviewed academic papers as the first or corresponding authors. And He has applied for 11 invention patents.


  1. 2012.08-2014.09 Postdoc, Institute of Georgia Technology, USA
  2. 2010.04-2012.07 Postdoc, University of South Carolina, USA
  3. PhD, Changchun Institute of Applied Chemistry Chinese Academy of Science, China

Academic Experience

  1. 2014-present: Researcher Professor, Wenzhou Institute, University of Chinese Academy of Science
  2. 2015-2017: Humboldt Scholar, Leibniz-Institute for Polymer Research Dresden

Research Interests

Zan has been engaged in the research of development of medical functional materials. Main research fields: (1) Design intracellular and in vivo delivery systems for biologically active molecules. (2) The influence of the physiochemical properties of the drug carrier in the delivery process. (3) The control of stem cell differentiation and the development of multifunctional implant coatings.

Selected Research Publications

  1. Zan X, Su Z. (2009) Counterions in polyelectrolyte multilayers: A vehicle for introducing functionalities. Thin Solid Films 116-9. (IF=1.879, JCR Q2)
  2. Zan X, Su Z. (2009) Incorporation of Nanoparticles into Polyelectrolyte Multilayers via Counterion Exchange and in situ Reduction. Langmuir 12355-60. (IF=4.001, JCR Q2)
  3. Zan X, Kozlov M, McCarthy TJ, Su Z. (2010) Covalently Attached, Silver-Doped Poly(vinyl alcohol) Hydrogel Films on Poly(L-lactic acid). Biomacromolecules 1082-8. (IF=5.862, JCR Q1)
  4. Zan X, Su Z. (2010) Polyelectrolyte multilayer films containing silver as antibacterial coatings. Thin Solid Films 5478-82. (IF=1.879, JCR Q2)
  5. Zan X, Peng B, Hoagland DA, Su Z. (2011) Polyelectrolyte uptake by PEMs: Impact of salt concentration. Polym Chem-Uk 2581-9. (IF=4.927, JCR Q1)
  6. Zhang X, Zan X, Su Z. (2011) Polyelectrolyte multilayer supported Pt nanoparticles as catalysts for methanol oxidation. J Mater Chem 17783-9. (IF=6.362, JCR Q1)
  7. Zan X, Hoagland DA, Wang T, Peng B, Su Z. (2012) Polyelectrolyte uptake by PEMs: Impacts of molecular weight and counterion. Polymer 5109-15. (IF=3.571, JCR Q2)
  8. Zan X, Hoagland DA, Wang T, Su Z. (2012) Ion Dispositions in Polyelectrolyte Multilayer Films. Macromolecules 8805-12. (IF=5.834, JCR Q1)
  9. Zan X, Sitasuwan P, Powell J, Dreher TW, Wang Q. (2012) Polyvalent display of RGD motifs on turnip yellow mosaic virus for enhanced stem cell adhesion and spreading. Acta Biomater 2978-85. (IF=6.503, JCR Q1)
  10. Zan X, Feng S, Balizan E, Lin Y, Wang Q. (2013) Facile Method for Large Scale Alignment of One Dimensional Nanoparticles and Control over Myoblast Orientation and Differentiation. Acs Nano 8385-96. (IF=13.429, JCR Q1)
  11. Li T, Zan X (共同一作), Winans RE, Wang Q, Lee B. (2013) Biomolecular Assembly of Thermoresponsive Superlattices of the Tobacco Mosaic Virus with Large Tunable Interparticle Distances. Angew Chem Int Edit 6638-42. (IF=11.827, JCR Q1)
  12. Zan X*, (2015) Engineering Polyelectrolyte Capsules with Independently Controlled Size and Shape Langmuir 31, 7601–7608 (IF=4.001, JCR Q2)
  13. Zan X*, Sitasuwan P, Sheng F, Wang Q. (2016) Effect of Roughness on in Situ Biomineralized CaP-Collagen Coating on the Osteogenesis of Mesenchymal Stem Cells  Langmuir 32, 1808–1817 (IF=4.001, JCR Q2)
  14. Wu Y, Jiang Zh,. Zan X*, Lin Y, Wang Q. (2017) Shear flow induced long-range ordering of rod like viral nanoparticles within hydrogel Colloids and Surfaces B: Biointerfaces 158, 620-626;  (IF=4.212, JCR Q2)
  15. Shi P, Luo S, Voit B, Appelhans D, Zan X*, (2018) A facile and efficient strategy to encapsulate the model basic protein lysozyme into porous CaCO3 J. Mater Chem. B 6, 4025-4215 (IF=4.776, JCR Q1)
  16. Zhang L, Hao P, Yang D, Feng S, Peng B, Appelhans D, Zhang T, Zan X*, (2019) Designing nanoparticles with improved tumor penetration: surface properties from the molecular architecture viewpoint J. Mater Chem. B 7, 953-964 (IF=4.776, JCR Q1)
  17. Yang S, Xu Y, Lin Q, Bai Y, Zan X*, (2019) A bio-inspired, one-step but versatile coating onto various substrates with strong antibacterial and enhanced osteogenesis Chem Comm 55, 2058-2061(IF=6.29, JCR Q1)
  18. Shi P, Qin J, Hu J, Bai Y, Zan X*, (2019) Insight into the mechanism and factors on encapsulating basic model protein, lysozyme, into heparin doped CaCO3 Colloids and Surfaces B: Biointerfaces 175, 184-194;  (IF=4.212, JCR Q2)
  19. Huang W, Hao P, Qin J, Luo S, Zhang T, Peng B, Chen H, Zan X*, (2019) Hexahistidine-metal assemblies: A promising drug delivery system Acta Biomater 441-452. (IF=6.503, JCR Q1)
  20. Huang W, Zhang T, Shi P, Yang D, Luo S, Voit B, Appelhans D, Chen H, Zan X*, (2019) The construction and effect of physical properties on intracellular drug delivery of poly(amino acid) capsules Colloids and Surfaces B: Biointerfaces 177, 178-187;  (IF=4.212, JCR Q2)
  21. Meng L, Li H, Pan Q, Gao C, Wang Y, Yang S, Zan X*, Guan Y, (2019) Graphene Oxide and Lysozyme Ultrathin Films with Strong Antibacterial and Enhanced Osteogenesis. Langmuir 6752-6761. (IF=4.001, JCR Q2)
  22. Zhang L,Wang Y, Yang D, Hao P, Feng S, Appelhans D, Zhang T, Zan X*, (2019) Shape effect of nanoparticles on tumour penetration in monolayers versus spheroids Molecular Pharmaceutics Accepted, DOI: mp-2019-00107a.R3  I(IF=4.556, JCR Q2)
  23. Yang S, Wang Y, Luo S, Shan C, Geng Y, Zhang T, Sheng S, Zan X*, Building polyphenol and gelatin films as implant coating, evaluating from in vitro and in vivo performances Colloids and Surfaces B: Biointerfaces 10.1016/j.colsurfb.2019.05.058; (IF=4.212, JCR Q2)
  24. Shi, P; Qin, J; Wu, X; Wang, L; Zhang, T; Yang, D; Zan X*, A Facile and Universal Method to Efficiently Fabricate Diverse Protein Capsules for Multiple Potential Applications ACS Applied Materials&Interfaces 39209-39218 (IF=8.634, JCR Q1)
  25. Yang Z, Wang P, Zhang Y, Zan X*, Zhu W, Jiang Y, Zhang L, Improved Ozonation Efficiency for Polymerization Mother Liquid from Polyvinyl Chloride Production Using Tandem Reactors Molecules DOI:10.3390/molecules24244436 (IF=3.06, JCR Q3)
  26. Yang S, Wang Y, Wu X, Sheng S, Wang T, Zan X*, Multifunctional Tannic Acid (TA) and Lysozyme (Lys) Films Built Layer by Layer for Potential Application on Implant Coating ACS Biomaterial Science&Engineering 3582-3594 (IF=4.513, JCR Q2)


  1. Xingjie Zan, Wenjuan Huang. A method based on polypeptide and metal organic coordination polymer for biological macromolecules encapsulation. 5
  2. Xingjie Zan, Wenjuan Huang. A preparation method of ph-responsive nanoparticles based on polypeptide and metal organic coordination. 9
  3. Xingjie Zan, Pengzhong Shi. A preparationmethod of polypeptide microcapsules by one-pot adsorption. 201711328419.X
  4. Xingjie Zan, Pengzhong Shi. A preparationmethod of polyprotein microcapsules in one-pot. 201711327499.7
  5. Xingjie Zan, Pengzhong Shi. A preparation method of cationic polyelectrolyte microcapsules by one-pot adsorption. 201711328281.3
  6. Xingjie Zan, Pengzhong Shi. A preparation method of polyamine compound microcapsules in one-pot. 201711328110.0
  7. Xingjie Zan, Shuoshuo Yang. A preparation method of self-assembled protein multilayer film. 201611139364.3
  8. Xingjie Zan, Shuoshuo Yang. Preparation method of self-assembled lysozyme multilayer film with antibacterial property and biocompatibility. 201710099816.8
  9. Xingjie Zan, Pengzhong Shi. Basic protein encapsulating carrier as well as its preparation and encapsulating method. 201610210632.X
  10. Xingjie Zan, Wenya Weng. A preparation method of polyelectrolyte microcapsules with independently controllable size and shape. 201510228624.3
  11. Xingjie Zan, Wenya Weng. A preparation method of polyelectrolyte hollow microcapsule with controllable size and shape as well as its application. 201510228416.3

Research Grants

  1. 2017.01-2019.12: National Natural Science Foundation of China (NSFC) “Influence of microenvironment on peripheral nerve regeneration in tubular three-dimensional system” (Grant No. 81601079) RMB 170,000
  2. 2015.09-2017.05: Alexander von Humboldt stifurg “Multi-level response capsule system with cross-linking regulation” RMB 530,000.
  3. 2014.10-2019.06: startup funding from Wenzhou Institute of Biomaterials&Engineering, “Novel drug delivery system” (WIBEZD2014002-02) RMB 3,000,000
  4. 2020.01-2020.12: Emergency research project from Wenzhou Science & Technology Bureau RMB 300,000
  5. 2019.07-2022.06 Major scientific research project of Wenzhou Institute of UCAS “Protein delivery system” (WIUCASQD2019009) RMB 3,000,000