Robert Belshaw, 博士

教育背景

1.英国帝国理工学院,生物学博士
2.英国曼彻斯特大学,动物学硕士、学士

学术经历

1.2013 – 2019 普利茅斯大学生物医学学院,基因组学副教授
2.2007 – 2012 牛津大学动物学系,疾病生物学系讲师(伍斯特和布兰森斯学院的讲师)
3.2005 – 2007 牛津大学,博士后研究助理
4.1994 – 2005 伦敦帝国理工学院,博士后研究助理

科研经费与奖项

1.2018 Project Lead, University of Plymouth Medical School education award: ‘OncoWiki: an interactive approach to teaching cancer genomics’. £5000
2.2017 Participant, EU Horizon 2020 project: ‘Integrated platform for brain cancer diagnostic techniques (AiPBAND)’. €3,700,000
3.2016 Co-Investigator, charity Action Medical Research grant: ‘The role of endogenous retroviral proteins in the development of Merlin-deficient tumours and their as potential as drug and immunotherapy targets’. £65,000
4.2016 Project Lead, University of Plymouth PedRIO (Pedagogic Research and Teaching Innovation Fund) award: ‘From OncoSim to OncoWiki: evaluating OncoSim’s educational effectiveness’. £8,500
5.2014 Co-Investigator, charity Action on Hearing Loss grant: ‘Endogenous Retroviral proteins as potential immunotherapy and/or drug targets for Merlin-deficient tumours treatment and their role in vestibular neuroma development’. £5,000
6.2009 Principal Investigator, Wellcome Trust project grant: ‘The evolution and present day activity of Endogenous Retroviruses’. £383,000

学术期刊出版物

1. Tatkiewicz W, Dickie J, Bedford F, Jones A, Atkin M, Kiernan M, Maze EA, Agit B, Farnham G, Kanapin A & Belshaw R (in press). Characterising a human endogenous retrovirus(HERV)-derived tumourassociated antigen: Enriched RNA-Seq analysis of HERV-K(HML-2) in Mantle Cell Lymphoma cell lines. Mobile DNA.
2. Schoenborn P, Osborne R, Toms N, Johnstone K, Milsom C, Muneer R, Jarvis MA & Belshaw R (2019) OncoSim and OncoWiki: an authentic learning approach to teaching cancer genomics. BMC Med Educ 19: 407.
3. Maze EA, Ham C, Kelly J, Ussher L, Almond N, Towers GJ, Berry N & Belshaw R (2019) Variable baseline Papio cynocephalus Endogenous Retrovirus (PcEV) expression is upregulated in acutely SIVinfected macaques and correlated to STAT1 expression in the spleen. Front Immunol 10: 901.
4. Li X, Wang H, Long J, Pan G, He T, Anichtchik O, Belshaw R, Albani D, Edison P, Green E & Scott J (2018) Systematic analysis and biomarker study for Alzheimer’s disease. Sci Rep 8: 17394.
5. Pavesi A, Vianelli A, Chirico N, Bao Y, Blinkova O, Belshaw R, Firth A & Karlin D (2018) Overlapping genes and the proteins they encode differ significantly in their sequence composition from non-overlapping genes. PLoS ONE 13: e0202513.
6. Long J, Pan G, Ifeachor E, Belshaw R & Li X (2016) Discovery of novel biomarkers for Alzheimer’s disease from blood. Dis Markers 2016: 4250480.
7. Magiorkinis G, Blanco-Melo D & Belshaw R (2015) The decline of human endogenous retroviruses: extinction and survival. Retrovirology 12: 8.
8. Li X, Long J, He T, Belshaw R & Scott J (2015) Integrated genomic approaches identify major pathways and upstream regulators in Late Onset Alzheimer’s Disease. Sci Rep 5: 12393.
9. Marchi E, Kanapin A, Magiorkinis G & Belshaw R (2014) Unfixed endogenous retroviral insertions in the human population. J Virol 88: 9529-37.
10. Katzourakis A, Magiorkinis G, Limb AG, Gupta S, Belshaw R & Gifford R (2014) Larger mammalian body size selects for lower retroviral activity. PLoS Pathog 10: e1004214.
11. Marchi E, Kanapin A, Byott M, Magiorkinis G & Belshaw R (2013) Neandertal and Denisovan retroviruses in modern humans. Curr Biol 23: R994-5.
12. Magiorkinis G, Belshaw R & Katzourakis A (2013) “There and back again”: revisiting the
pathophysiological roles of human endogenous retroviruses in the post-genomic era. Philos Trans R Soc Lond B Biol Sci 368: 20120504.
13. Magiorkinis G, Sypsa V, Magiorkinis E, Paraskevis D, Katsoulidou A, Belshaw R, Fraser C, Pybus OG & Hatzakis A (2013) Integrating phylodynamics and epidemiology to estimate transmission diversity in viral epidemics. PLoS Comp Biol 9: e1002876.
14. Paraskevis D, Magiorkinis G, Magiorkinis E, Ho SYW, Belshaw R, Allain J-P & Hatzakis A (2012) Dating the origin and dispersal of Hepatitis B Virus infection in humans and primates. Hepatology 57: 908-16.
15. Magiorkinis G, Gifford RJ, Katzourakis A, De Ranter J & Belshaw R (2012) Env-less endogenous retroviruses are genomic superspreaders. PNAS 109: 7385-90.
16. Karlin D & Belshaw R (2012) Detecting remote sequence homology in disordered proteins: discovery of conserved motifs in the N-termini of Mononegavirales phosphoproteins. PLoS ONE 7: e31719.
17. Belshaw R, Sanjuán R & Pybus OG. (2011) Viral mutation and substitution: units and levels. Curr Opin Virol 1: 430-5.
18. Chirico N, Vianelli A & Belshaw R (2010) Why genes overlap in viruses. Proc Biol Sci 277: 3809-17.
19. Sanjuán R, Nebot MR, Chirico N, Mansky LM & Belshaw R (2010) Viral mutation rates. J Virol 84: 9733-48.
20. Belshaw R, de Oliviera T, Markowitz S & Rambaut A (2009) The RNA Virus Database. Nucleic Acids Res 37: D431-5.
21. Belshaw R, Gardner A, Rambaut A & Pybus OG (2008) Pacing a small cage: mutation and RNA viruses.Trends Ecol Evol 23: 188-93
22. Armitage AE, Katzourakis A, de Oliveira T, Welch JJ, Belshaw R, Bishop KN, Kramer B, McMichael AJ, Rambaut A & Iversen AKN (2008) Conserved footprints of APOBEC3G on hypermutated HIV-1 and HERV-K(HML2) sequences. J Virol 82: 8743-61.
23. Belshaw R, Pybus OG & Rambaut A (2007) The evolution of genome compression and genomic novelty in RNA viruses. Genome Res 17: 1496-504.
24. Belshaw R, Watson J, Katzourakis A, Howe A, Woolven-Allen J, Burt A & Tristem M (2007) Rate of recombinational deletion among human endogenous retroviruses. J Virol 81: 9437-42.
25. Pybus OG, Rambaut A, Belshaw R, Freckleton RP, Drummond AJ & Holmes EC (2007) Phylogenetic evidence for deleterious mutation load in RNA viruses and its contribution to viral evolution. Mol Biol Evol 24: 845-52.
26. Belshaw R & Bensasson D (2006) The rise and falls of introns. Heredity 96: 208-13.
27. Belshaw R, Dawson A, Woolven-Allen J, Redding J, Burt A & Tristem M (2005) Genomewide screening reveals high levels of insertional polymorphism in the human endogenous retrovirus family HERVK(HML2): implications for present day activity. J Virol 79: 12507-14.
28. Belshaw R, Katzourakis A, Paces J, Burt A & Tristem M (2005) High copy number in human endogenous retrovirus (HERV) families is associated with copying mechanisms in addition to re-infection. Mol Biol Evol 22: 814-7.
29. Belshaw R & Katzourakis A (2005) BlastAlign: a program that uses blast to align problematic nucleotide sequences. Bioinformatics 21: 122-3.
30. Belshaw R, Pereira V, Katzourakis A, Talbot G, Paces J, Burt A & Tristem M (2004) Long-term reinfection of the human genome by endogenous retroviruses. PNAS 101: 4894-9.
31. Veen FJF van, Belshaw R & Godfray HCJ (2003) The value of the ITS2 region for the identification of species boundaries between Alloxysta hyperparasitoids (Hymenoptera: Charipidae) of aphids. Eur J Entomol 100: 449-53.
32. Belshaw R, Grafen A & Quicke DLJ (2003) Inferring life history from ovipositor morphology in parasitoid wasps using phylogenetic regression and discriminant analysis. Zool J Linn Soc 139: 213-28.
33. Belshaw R & Quicke DLJ (2003) The cytogenetics of thelytoky in a predominantly asexual parasitoid wasp with covert sex. Genome 46: 170-3.
34. Manzari S, Polaszek A, Belshaw R & Quicke DLJ (2002) Morphometric and molecular analysis of the Encarsia inaron species-group (Hymenoptera: Aphelinidae), parasitoids of whiteflies (Hemiptera: Aleyrodidae). Bull Entomol Res 92: 165-75
35. Dowton M, Belshaw R, Austin AD & Quicke DLJ (2002) Simultaneous molecular and morphological analysis of braconid relationships (Insecta: Hymenoptera: Braconidae) indicates independent mt-tRNA gene inversions within a single wasp family. J Mol Evol 54: 210-26.
36. Belshaw R & Quicke DLJ (2002) Robustness of ancestral state estimates: evolution of life history strategy in ichneumonoid parasitoids. Syst Biol 51: 450-77.
37. Belshaw R, Lopez-Vaamonde C, Degerli N & Quicke DLJ (2001) Paraphyletic taxa and taxonomic chaining: evaluating the classification of braconine wasps (Hymenoptera: Braconidae) using 28S D2-3 rDNA sequences and morphological characters. Biol J Linn Soc 73: 411-24.
38. Sanchis A, Michelena JM, Latorre A, Quicke DLJ, Gärdenfors U & Belshaw R (2001) The phylogenetic analysis of variable length sequence data: elongation factor-1a introns in European populations of the parasitoid wasp Pauesia (Hymenoptera: Braconidae: Aphidiinae). Mol Biol Evol 18: 1117-31.
39. Belshaw R, Dowton M, Quicke DLJ & Austin AD (2000) Estimating ancestral geographic distributions: a Gondwanan origin for aphid parasitoids? Proc Biol Sci 267: 491-496.
40. Basibüyük H, Bardakci F, Belshaw R & Quicke DLJ (2000) Phylogenetic Systematics: a Guide to Theory and Practice. Cumhuriyet University Press, Sivas, Turkey. 134pp.
41. Dolphin K, Belshaw R, Orme CDL & Quicke DLJ (2000) Noise and incongruence: interpreting results of the Incongruence Length Difference Test. Mol Phylogenet Evol 17: 401-6.
42. Laurenne NM, Belshaw R, Broad G & Quicke DLJ (2000) Molecular confirmation of host records for ichneumonoid parasitoids of wood-boring beetle larvae. J Hymenopt Res 9: 241-5.
43. Belshaw R, Quicke, DLJ, Völkl, W. & Godfray HCJ (1999) Molecular markers indicate rare sex in a predominantly asexual parasitoid wasp. Evolution 53: 1189-99.
44. Quicke DLJ & Belshaw R (1999) Incongruence between morphological data sets: an example from the evolution of endoparasitism among parasitic wasps (Hymenoptera: Braconidae). Syst Biol 48: 436-54.
45. Quicke DLJ, Belshaw R & Lopez-Vaamonde C (1999) Preservation of hymenopteran specimens for subsequent molecular and morphological study. Zool Scr 28: 261-67.
46. Quicke DLJ, Lopez-Vaamonde C & Belshaw R (1999) The basal Ichneumonidae (Insecta: Hymenoptera): 28S D2 rDNA considerations of the Brachycyrtinae, Labeninae, Paxylommatinae and Xoridinae. Zool Scr 28: 203-10.
47. Müller CB, Adriaanse ICT, Belshaw R & Godfray HCJ (1999) The structure of an aphid-parasitoid community. J Anim Ecol 68: 346-70.
48. Belshaw R, Fitton M, Herniou E, Gimeno C & Quicke DLJ (1998) A phylogenetic reconstruction of the Ichneumonoidea (Hymenoptera) based on the D2 variable region of 28S ribosomal RNA. Syst Entomol 23: 109-23.
49. Belshaw R & Quicke DLJ (1997) A molecular phylogeny of the Aphidiinae (Hymenoptera: Braconidae). Mol Phylogenet Evol 7: 281-93.
50. Gimeno C, Belshaw R & Quicke DLJ (1997) Phylogenetic relationships of the Alysiinae/Opiinae (Hymenoptera: Braconidae) and the utility of cytochrome b, 16S and 28S D2 rRNA. Insect Mol Biol 6: 273-84.